BPC 157 (Body Protection Compound-157) is a pentadecapeptide made up of 15 amino acids. The amino acids sequence in BPC 157 is similar to a portion of the human BPC amino acid sequence. Human BPC is found in the gastric juice. Experiments have shown that BPC 157 enhances the healing of wounds, including tendons wounds such as transected Achilles tendons of rats. The aim of this study was to investigate the probable mechanism that BPC 157 utilizes to accelerate the healing process in an injured tendon.
The study used two group of tendon explants of which one group was cultured in a BPC 157-containing medium while the other group was cultured in a medium lacking BPC 157. These cultures were thereafter examined for tendon fibroblasts outgrowths. Such outgrowths indicated tendon regeneration.The results revealed that the explants' outgrowth was significantly accelerated in the culture containing BPC 157 as compared to the culture lacking BPC 157.
Also, a MTT assay did show that BPC 157 does not directly affect cellular proliferation in a culture of rat-derived Achilles tendon. However, results also showed that BPC 157 significantly increased the survival of cells under oxidative stress. Furthermore, the Transwell filter migration assay showed that BPC 157 significantly increased in-vitro fibroblast migration in a dose-dependent fashion. Moreover, BPC 157 accelerated the dispersal of the fibroblasts in culture dishes in a dose-dependent manner.
BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models.In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease.BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect.In addition, it significantly facilitates the healing of bone fracture in rats.This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect.BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.
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Because BPC 157 has proven to be isolated from gastric juices, it should not be a surprise to find that various scientific studies that have been conducted on animal test subjects have been able to pinpoint several links between the peptide's presence and digestive tract functionality. Specifically, it has been determined that BPC 157 exhibits the capacity to regulate and control the manner in which the digestive tract can operate.
One of the ways that BPC 157 accomplishes this is through safeguarding the endothelium, which is the thin layer of cells that line the blood vessels' interior surface. Another way the peptide carries out regulatory function is by being a key factor in the process of angiogenesis; that is, the process in which new blood vessels are formed from pre-existing blood vessels.
This latter process is further bolstered by BPC 157's ability to form granulation tissue; this term references the new connective tissues and tiny blood vessels that develop on the surface of wound, thus making the peptide an important piece to the overall wound healing process. Further studies have also shown that the peptide's inherent functionality allows it to contain anti-inflammatory properties. Additionally, these studies have determined that BPC 157 can also help in the regulation and control of blood flow throughout an animal test subject's gastro-intestinal tract.
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